Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic PillarArene Modified Gold Nanoparticles. Sensors2018, 18, 3927.
Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic PillarArene Modified Gold Nanoparticles. Sensors 2018, 18, 3927.
A supramolecular host-guest interaction and sensing between cationic pillararenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles ([email protected]) as receptor and probe (rhodamine 123, R123), which shown a high sensitivity and selectivity to L-carnitine detection. Due to the property of the negative charge and molecular size of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The mechanism of host-guest between PP5 and L-carnitine was studied by 1H NMR and molecular docking, which indicated more affinity binding force of PP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1–2.0 and 2.0–25.0 μM and a detection limit of 0.067 μM (S/N = 3) for L-carnitine. The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications of detection drugs of abuse, and had path for guarding a serious food safety issues.
cationic pillararenes; host–guest recognition; Au nanoparticles; L-carnitine
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