Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Novel Competitive Fluorescence Sensing Platform for L-Carnitine Based on Cationic Pillar[5]arene Modified Gold Nanoparticles

Xiaoping Tan
* ORCID logo ,
Yang Yang
,
Shasha Luo
,
Zhong Zhang
,
Wenjie Zeng
,
Tingying Zhang
,
Fawu Su
* ORCID logo ,
Linzong Zhou
*
Version 1 : Received: 22 October 2018 / Approved: 24 October 2018 / Online: 24 October 2018 (11:35:05 CEST)

A peer-reviewed article of this Preprint also exists.

Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles. Sensors 2018, 18, 3927. Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles. Sensors 2018, 18, 3927.

Abstract

A supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles (PP5@Au-NPs) as receptor and probe (rhodamine 123, R123), which shown a high sensitivity and selectivity to L-carnitine detection. Due to the property of the negative charge and molecular size of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The mechanism of host-guest between PP5 and L-carnitine was studied by 1H NMR and molecular docking, which indicated more affinity binding force of PP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1–2.0 and 2.0–25.0 μM and a detection limit of 0.067 μM (S/N = 3) for L-carnitine. The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications of detection drugs of abuse, and had path for guarding a serious food safety issues.

Keywords

cationic pillar[5]arenes; host–guest recognition; Au nanoparticles; L-carnitine

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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