Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Version 1 : Received: 22 October 2018 / Approved: 22 October 2018 / Online: 22 October 2018 (15:35:20 CEST)

A peer-reviewed article of this Preprint also exists.

Antimisiaris, S.G.; Mourtas, S.; Marazioti, A. Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery. Pharmaceutics 2018, 10, 218. Antimisiaris, S.G.; Mourtas, S.; Marazioti, A. Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery. Pharmaceutics 2018, 10, 218.

Journal reference: Pharmaceutics 2018, 10, 218
DOI: 10.3390/pharmaceutics10040218

Abstract

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges identified up-to-date in this field are summarized.

Keywords

liposomes, exosomes, extracellular vesicles, drug delivery, drug targeting, bioinspired systems, engineered systems.

Subject

LIFE SCIENCES, Other

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