Preprint Article Version 1 This version is not peer-reviewed

Investigation of Disintegration and Dissolution Behavior of Mefenamic Acid Drug Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata Model on Microtomographic Surfaces and Rational Arrangements of Tablet Components

Version 1 : Received: 21 October 2018 / Approved: 22 October 2018 / Online: 22 October 2018 (11:38:04 CEST)

A peer-reviewed article of this Preprint also exists.

Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics 2018, 10, 259. Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics 2018, 10, 259.

Journal reference: Pharmaceutics 2018, 10, 259
DOI: 10.3390/pharmaceutics10040259

Abstract

There are numerous approaches to model an influence of manufacturing parameters on the dissolution and disintegration of solid dosage forms. A modern approach for modelling and simulating complex and heterogeneous systems such as pharmaceutical tablets focuses on computationally-intensive finite-element or discreet element methods. Industrial challenges such as Process Analytical Technology (PAT) and Quality by Design are stimulating computer-based technologies to design, control and improve the quality of pharmaceutical compacts and their performance. In this study the disintegration and dissolution model based on the numerical solutions of the Noyes-Whitney equation and cellular automata supported disintegration model are proposed and evaluated. The results from in vitro release studies of the mefenamic acid formulations were compared to the calculated release patterns from the tablet structures obtained from microtomography experiments and the purely algorithmically created virtual tablets.

Subject Areas

drug release simulation; disintegration simulation; poorly water soluble drug; mefenamic acid; Noyes-Whitney equation; cellular automata; synchrotron microtomography

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.