Fusaproliferin, a Fungal Phytotoxin Shows Rapid and Potent Cytotoxicity against Pancreatic Cancer Cell Lines

Nazia Hoque; Choudhury Mahmood Hasan; Md. Sohel Rana; Amrit Varsha; Md. Hossain Sohrab; Khondaker Miraz Rahman

doi:10.20944/preprints201810.0375.v1

A peer-reviewed article of this Preprint also exists.

Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288. Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288.

Journal reference: Molecules 2018, 23, 3288
DOI: 10.3390/molecules23123288

Abstract

As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from Fusarium solani strain associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC₅₀ against pancreatic cancer cell lines. Time dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 hours after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.

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Fusaproliferin, a Fungal Phytotoxin Shows Rapid and Potent Cytotoxicity against Pancreatic Cancer Cell Lines

Abstract

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