Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules2018, 23, 3288.
Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288.
Abstract
As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from Fusarium solani strain associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 hours after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
Keywords
endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer
Subject
CHEMISTRY, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Nazia Hoque
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