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Fusaproliferin, a Fungal Phytotoxin Shows Rapid and Potent Cytotoxicity against Pancreatic Cancer Cell Lines
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Version 1
: Received: 17 October 2018 / Approved: 17 October 2018 / Online: 17 October 2018 (06:39:51 CEST)
A peer-reviewed article of this Preprint also exists.
Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288. Hoque, N.; Hasan, C.M.; Rana, M.S.; Varsha, A.; Sohrab, M.H.; Rahman, K.M. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines. Molecules 2018, 23, 3288.
Journal reference: Molecules 2018, 23, 3288
DOI: 10.3390/molecules23123288
Abstract
As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from Fusarium solani strain associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 hours after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
Keywords
endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer
Subject
CHEMISTRY, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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