Preprint Review Version 1 This version is not peer-reviewed

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

Version 1 : Received: 15 October 2018 / Approved: 15 October 2018 / Online: 15 October 2018 (16:57:44 CEST)

A peer-reviewed article of this Preprint also exists.

Wong, A. .-A.; Xiang, X.; Ong, P.S.; Mitchell, E.Q.Y.; Syn, N.; Wee, I.; Kumar, A.P.; Yong, W.P.; Sethi, G.; Goh, B.C.; Ho, P. .-L.; Wang, L. A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs. Pharmaceutics 2018, 10, 221. Wong, A. .-A.; Xiang, X.; Ong, P.S.; Mitchell, E.Q.Y.; Syn, N.; Wee, I.; Kumar, A.P.; Yong, W.P.; Sethi, G.; Goh, B.C.; Ho, P. .-L.; Wang, L. A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs. Pharmaceutics 2018, 10, 221.

Journal reference: Pharmaceutics 2018, 10, 221
DOI: 10.3390/pharmaceutics10040221

Abstract

In the last decade, the tremendous improvement in the sensitivity and also affordability of Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) have revolutionized its application in pharmaceutical analysis, resulting in wide-spread of employing LC-MS/MS for determining pharmaceutical compounds including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical Pharmacokinetic studies in R & D of oncology drugs. This mini-review article will describe the state-of-the art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation and matrix effect evaluation.

Subject Areas

LC-MS/MS, Rapid, Quantification, Oncology Drugs

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