Preprint Article Version 1 This version is not peer-reviewed

Human Amniotic Membrane Preparation, Preservation and Clinical Application Using Various Techniques for the Treatment of Ophthalmic Dysfunctions

Version 1 : Received: 10 October 2018 / Approved: 15 October 2018 / Online: 15 October 2018 (14:35:06 CEST)

How to cite: Hossain, L.; Arifuzzaman, M.; Diba, F.; Siddika, A.; Adnan, M.; Akhtar, N.; Hasan, M.Z.; Asaduzzaman, S. Human Amniotic Membrane Preparation, Preservation and Clinical Application Using Various Techniques for the Treatment of Ophthalmic Dysfunctions. Preprints 2018, 2018100321 (doi: 10.20944/preprints201810.0321.v1). Hossain, L.; Arifuzzaman, M.; Diba, F.; Siddika, A.; Adnan, M.; Akhtar, N.; Hasan, M.Z.; Asaduzzaman, S. Human Amniotic Membrane Preparation, Preservation and Clinical Application Using Various Techniques for the Treatment of Ophthalmic Dysfunctions. Preprints 2018, 2018100321 (doi: 10.20944/preprints201810.0321.v1).

Abstract

The aim of this study is to emphasize on the clinical uses of amniotic membrane (AM) in multiple ocular disorders. AM possesses many properties including promotion of epithelialization, anti-fibrotic, anti-apoptotic, anti-angiogenic properties. Epithelial wound healing on the eye surface is promoted due to several epidermal and keratocyte growth factors as well as by its anti-inflammatory and anti-scarring effects due to interleukin-10, interleukin-1 receptor antagonists and inhibition of transforming growth factor- beta (TGF-β) signal transduction by AM in the corneal and conjunctival fibroblasts respectively. It plays a crucial role by functioning as a substitute of basement membrane (BM) and as a temporary graft material. It is not only being used as an eye graft but also its extract can be used as an eye drop for corneal and external eye diseases. So its proper preparation, preservation and clinical application can bring a revolutionary change in the treatment of different ocular disorders.

Subject Areas

amniotic membrane; epithelialization; inflammation; ocular surface disorders; anti-fibrotic action, amniotic membrane eye drop, amniotic membrane graft transplantation

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.