Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes

Pablo Chagas; Graziella Sousa; Marcio Kodama; Carlos Biagi Junior; José Yunes Andres; Silvia Brandalise; George Calin; Luiz Tone; Carlos Scrideli; Jaqueline Oliveira

doi:10.20944/preprints201810.0163.v1

How to cite: Chagas, P.; Sousa, G.; Kodama, M.; Biagi Junior, C.; Andres, J.Y.; Brandalise, S.; Calin, G.; Tone, L.; Scrideli, C.; Oliveira, J. Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes. Preprints 2018, 2018100163. https://doi.org/10.20944/preprints201810.0163.v1 Chagas, P.; Sousa, G.; Kodama, M.; Biagi Junior, C.; Andres, J.Y.; Brandalise, S.; Calin, G.; Tone, L.; Scrideli, C.; Oliveira, J. Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes. Preprints 2018, 2018100163. https://doi.org/10.20944/preprints201810.0163.v1

Abstract

Long non-coding RNA (lncRNA) aberrant expression have been found in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped in transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated in pediatric ALL and uc.112 expression was higher in T-ALL compared to patients with B-ALL and in patients with hyperdiploid karyotype. These findings suggest a potential role of this uc.112 in pediatric ALL and emphasize the need for further investigation of T-UCR in pediatric ALL.

Keywords

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes

Abstract

Keywords

Subject

Comments (0)