Preprint Article Version 1 This version is not peer-reviewed

Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes

Version 1 : Received: 8 October 2018 / Approved: 8 October 2018 / Online: 8 October 2018 (17:01:03 CEST)

How to cite: Chagas, P.; Sousa, G.; Kodama, M.; Biagi Junior, C.; Andres, J.Y.; Brandalise, S.; Calin, G.; Tone, L.; Scrideli, C.; Oliveira, J. Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes. Preprints 2018, 2018100163 (doi: 10.20944/preprints201810.0163.v1). Chagas, P.; Sousa, G.; Kodama, M.; Biagi Junior, C.; Andres, J.Y.; Brandalise, S.; Calin, G.; Tone, L.; Scrideli, C.; Oliveira, J. Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes. Preprints 2018, 2018100163 (doi: 10.20944/preprints201810.0163.v1).

Abstract

Long non-coding RNA (lncRNA) aberrant expression have been found in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped in transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated in pediatric ALL and uc.112 expression was higher in T-ALL compared to patients with B-ALL and in patients with hyperdiploid karyotype. These findings suggest a potential role of this uc.112 in pediatric ALL and emphasize the need for further investigation of T-UCR in pediatric ALL.

Subject Areas

T-UCR; pediatric acute lymphoblastic leukemia; uc.112; T-ALL; hyperdiploidy.

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