Preprint Review Version 1 This version is not peer-reviewed

Epilepsy in Children: From Diagnosis to Treatment

Version 1 : Received: 5 October 2018 / Approved: 6 October 2018 / Online: 6 October 2018 (11:38:35 CEST)

A peer-reviewed article of this Preprint also exists.

Minardi, C.; Minacapelli, R.; Valastro, P.; Vasile, F.; Pitino, S.; Pavone, P.; Astuto, M.; Murabito, P. Epilepsy in Children: From Diagnosis to Treatment with Focus on Emergency. J. Clin. Med. 2019, 8, 39. Minardi, C.; Minacapelli, R.; Valastro, P.; Vasile, F.; Pitino, S.; Pavone, P.; Astuto, M.; Murabito, P. Epilepsy in Children: From Diagnosis to Treatment with Focus on Emergency. J. Clin. Med. 2019, 8, 39.

Journal reference: J. Clin. Med. 2019, 8, 39
DOI: 10.3390/jcm8010039

Abstract

Seizures are defined as a transient occurrence of signs and symptoms due to the abnormal, excessive or synchronous neuronal activity in the brain characterized by an abrupt and involuntary skeletal muscles activity. An early diagnosis, treatment and specific medical support must be performed to prevent Status Epilepticus (SE). Seizures’ onset, especially in children population, is related to specific risk factors like positive family history, fever, infections, neurological comorbidity, premature birth, mother’s alcohol abuse and smoke in pregnancy. Early death risk in children without neurological comorbidity is similar to the general population. Diagnosis is generally based on the identification of continuous or recurrent seizures but EEG evaluation could be useful if SE condition in suspected. The main goal of therapy is to contrast pathological mechanism which occurs in SE before neural cells are irreversibly damaged. According to latest International Guidelines and Recommendations of seizures’ related diseases, it is proposed a schematic and multi-stage pharmacological and diagnostic approach especially in the management of SE and its related causes in children. First measures should focus on early and appropriate drugs administration at adequate dosage, airway management, monitoring vital signs, PICU admission and management of parents’ anxiety.

Subject Areas

seizures; status epilepticus; children

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