Version 1
: Received: 19 September 2018 / Approved: 19 September 2018 / Online: 19 September 2018 (13:59:33 CEST)
How to cite:
Orlando, P.; Silvestri, S.; Marcheggiani, F.; Cirilli, I.; Tiano, L. Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile. Preprints2018, 2018090386. https://doi.org/10.20944/preprints201809.0386.v1
Orlando, P.; Silvestri, S.; Marcheggiani, F.; Cirilli, I.; Tiano, L. Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile. Preprints 2018, 2018090386. https://doi.org/10.20944/preprints201809.0386.v1
Orlando, P.; Silvestri, S.; Marcheggiani, F.; Cirilli, I.; Tiano, L. Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile. Preprints2018, 2018090386. https://doi.org/10.20944/preprints201809.0386.v1
APA Style
Orlando, P., Silvestri, S., Marcheggiani, F., Cirilli, I., & Tiano, L. (2018). Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile. Preprints. https://doi.org/10.20944/preprints201809.0386.v1
Chicago/Turabian Style
Orlando, P., Ilenia Cirilli and Luca Tiano. 2018 "Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile" Preprints. https://doi.org/10.20944/preprints201809.0386.v1
Abstract
Menaquinone-7 is a member of the vitamin K family whose interest has considerably increased over the last decade due to its beneficial role in human health mainly in respect to bone and cardiovascular health leading to a growing use in different nutritional supplement. Menaquinone-7 can be produced by synthesis or fermentation and its purity profile can differ depending on methodologies and extraction procedures. Finished formulation show a large heterogeneity of purity profiles as well as frequent discrepancies in the nominal content compared to the actual title. In the present study we compared purity profiles of different raw material and we related them to stability assay in normal (12months/25°C/60%RH) and accelerated conditions (6 months/40°C/75% RH) in order to test their performance in presence of different common excipients. Results show that higher purity profile correlates with enhanced stability and this could explain title discrepancies found in finished products found on the market worldwide.
Keywords
menaquinone-7, stability, purity, food supplement
Subject
Chemistry and Materials Science, Food Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.