Version 1
: Received: 13 September 2018 / Approved: 18 September 2018 / Online: 18 September 2018 (11:53:28 CEST)
How to cite:
Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1).
Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints 2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1).
Cite as:
Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1).
Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints 2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1).
Abstract
The development of a method to produce coumarins unsubstituted on the pyranic nucleus catalyzed from Wells–Dawson heteropolyacid (H6P2W18O62), phenol derivatives and ethyl 3,3-diethoxypropionate using Pechmann condensation under solvent-free conditions is described. This catalytic method was also applied successfully to synthesize various substituted coumarins, including the corresponding phenols and ethyl 3,3-diethoxypropionate. This work provides a novel, cheaper and safer way to syhthesize coumarins unsubstituted on the pyranic nucleus.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Yu-Feng Sun
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