Preprint Article Version 1 This version is not peer-reviewed

One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62)

Version 1 : Received: 13 September 2018 / Approved: 18 September 2018 / Online: 18 September 2018 (11:53:28 CEST)

How to cite: Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints 2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1). Sun, Y.; Liu, J.; Sun, J.; Huang, Y.; Lu, J.; Li, M.; Jin, N.; Dai, X.; Fan, B. One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H6P2W18O62). Preprints 2018, 2018090349 (doi: 10.20944/preprints201809.0349.v1).

Abstract

The development of a method to produce coumarins unsubstituted on the pyranic nucleus catalyzed from Wells–Dawson heteropolyacid (H6P2W18O62), phenol derivatives and ethyl 3,3-diethoxypropionate using Pechmann condensation under solvent-free conditions is described. This catalytic method was also applied successfully to synthesize various substituted coumarins, including the corresponding phenols and ethyl 3,3-diethoxypropionate. This work provides a novel, cheaper and safer way to syhthesize coumarins unsubstituted on the pyranic nucleus.

Subject Areas

coumarin; one-pot synthesis; catalysis; Wells–Dawson heteropolyacid

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