Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Notch and Breast Cancer Metastasis

Version 1 : Received: 17 September 2018 / Approved: 17 September 2018 / Online: 17 September 2018 (11:54:19 CEST)

How to cite: Zhang, Y.; Deng, H. Notch and Breast Cancer Metastasis. Preprints 2018, 2018090307. Zhang, Y.; Deng, H. Notch and Breast Cancer Metastasis. Preprints 2018, 2018090307.


Metastasis is a major cause factor for breast cancer (BC)-associated mortality. During the metastatic process, disseminated tumor cells (DTCs) detach from the primary sites, and enter the bloodstream and establish the secondary colonies. Recent studies have provided substantial evidence for the importance of Notch signaling in BC metastasis. Therefore, this review focuses on the mechanisms by which Notch contributes to the origin of BC DTCs, increases their motility, regulates their intravasation and extravasation, protects them from host surveillance, and finally facilitates colonization. Identification of the mechanisms underlying Notch-related BC metastasis will lead to the development of novel Notch-targeted therapeutic strategies to reduce metastasis and significantly improve outcomes.


breast cancer; metastasis; Notch; Jagged-1; Dll4


Biology and Life Sciences, Biochemistry and Molecular Biology

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