Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease

Benjamin Jenkins
ORCID logo ,
Manar Aoun
,
Christine Feillet-Coudray
,
Charles Coudray
,
Martin Ronis
,
Albert Koulman
* ORCID logo
Version 1 : Received: 14 September 2018 / Approved: 15 September 2018 / Online: 15 September 2018 (17:49:08 CEST)

A peer-reviewed article of this Preprint also exists.

Jenkins, B.; Aoun, M.; Feillet-Coudray, C.; Coudray, C.; Ronis, M.; Koulman, A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutrients 2018, 10, 1646. Jenkins, B.; Aoun, M.; Feillet-Coudray, C.; Coudray, C.; Ronis, M.; Koulman, A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutrients 2018, 10, 1646.

Abstract

Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) have been described as dietary biomarkers of dairy-fat consumption with varying degrees of reliability between studies. It remains unclear how the total amount of dietary fat; one of the main confounding factors in these biomarker investigations, affects C15:0 and C17:0 circulating compositions independently to their relative intake. Additionally, it is unknown how changes in the dietary total-fat affects other fatty acids in circulation. Through two dietary studies with different total-fat levels but maintaining individual fatty acid compositions we were able to see how the dietary total-fat affects the fatty acids in circulation. We saw that there was a significant, proportionate, and robust decrease in the endogenous C15:0 levels with an increase in dietary total-fat. However, there was an increase in the circulating C17:0 compositions as the total-fat increased. To conclude, the dietary total-fat content and fat-type have a very complex influence on the relative compositions of circulating fatty acids, which are independent to the actual dietary fatty acid composition. Knowing how to manipulate circulating C15:0 and C17:0 composition is far-reaching in nutritional/pathological research as they highlight a dietary route to attenuate the development of metabolic disease (both by reducing risk and improving prognosis).

Keywords

Biomarkers; dietary total fat; pentadecanoic acid; 15:0; heptadecanoic acid; 17:0; odd chain fatty acids.

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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