Angelopoulou, M.; Kakabakos, S.; Petrou, P. Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers. Chemosensors2018, 6, 52.
Angelopoulou, M.; Kakabakos, S.; Petrou, P. Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers. Chemosensors 2018, 6, 52.
The article reviews the current status of label-free integrated optical sensors focusing on the evolution over the years of their analytical performance. At first a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical sensors including sensors based on surface plasmon resonance (SPR), grating coupler, photonic crystals, ring resonators and interferometric transducers. After a short reference to SPR techniques, including localized SPR, integrated optical sensors i.e., grating-couplers, interferometers, photonic crystals, microring resonators are reviewed. For each type of sensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free biosensors optical sensors is provided
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