Preprint Review Version 1 This version is not peer-reviewed

Modeling Membrane-Protein Interactions

Version 1 : Received: 4 September 2018 / Approved: 4 September 2018 / Online: 4 September 2018 (05:13:10 CEST)

A peer-reviewed article of this Preprint also exists.

Alimohamadi, H.; Rangamani, P. Modeling Membrane Curvature Generation due to Membrane–Protein Interactions. Biomolecules 2018, 8, 120. Alimohamadi, H.; Rangamani, P. Modeling Membrane Curvature Generation due to Membrane–Protein Interactions. Biomolecules 2018, 8, 120.

Journal reference: Biomolecules 2018, 8, 120
DOI: 10.3390/biom8040120

Abstract

In order to alter and adjust the shape of the membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane proteins, integral membrane proteins, and lipids in the bilayer membrane. One of the challenges in modeling these processes is identifying the suitable constitutive relationships that describe the membrane free energy that includes protein distribution and curvature generation capability. Here, we review some of the commonly used continuum elastic membrane models that have been developed for this purpose and discuss their applications. Finally, we address some fundamental challenges that future theoretical methods need to overcome in order to push the boundaries of current model applications.

Subject Areas

plasma membrane; spontaneous curvature; Helfrich energy; area difference elastic model; protein crowding; Deviatoric curvature

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