Preprint Review Version 1 This version is not peer-reviewed

Microfluidic Advancements in Classical Biotechnology – A Review

Version 1 : Received: 15 August 2018 / Approved: 15 August 2018 / Online: 15 August 2018 (05:37:59 CEST)

A peer-reviewed article of this Preprint also exists.

Ahmed, I.; Akram, Z.; Bule, M.H.; Iqbal, H.M.N. Advancements and Potential Applications of Microfluidic Approaches—A Review. Chemosensors 2018, 6, 46. Ahmed, I.; Akram, Z.; Bule, M.H.; Iqbal, H.M.N. Advancements and Potential Applications of Microfluidic Approaches—A Review. Chemosensors 2018, 6, 46.

Journal reference: Chemosensors 2018, 6, 46
DOI: 10.3390/chemosensors6040046

Abstract

Micro-technology has played a substantial role in bioscience, biomedical and biotechnological research due to its core advantages in modern science and engineering. It has created unique development in various sectors of bio-research and upsurges the efficacy of research at the molecular level in recent years. Microfluidic technology makes it possible to manipulate sample volumes at the micro- and nano-level (called nanofluidics) with terrific control outside in vivo cellular microenvironment, enabling the reduction of discrepancies between in vivo and in vitro environments as well as reducing reaction time and cost. In this review, we discuss various effective integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bio-research, supporting mechanical and chemical in vitro cellular micro-environment. Specific innovations relating to the application of microfluidics to advance microbial life, solitary and co-cultures along with a multiple-type cell culturing, cellular communications, cellular interactions and population dynamics are discussed.

Subject Areas

microchannel; micro-array; microstructure; biofilms; polydimethylsiloxane; Micro-PCR; reynolds number; micro electro mechanical systems

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