Preprint Article Version 1 This version is not peer-reviewed

Fluorescent Nanosensor based on Molecularly Imprinted Polymers Coated on Graphene Quantum Dots for Fast Detection of Antibiotics

Version 1 : Received: 13 July 2018 / Approved: 16 July 2018 / Online: 16 July 2018 (11:42:03 CEST)

A peer-reviewed article of this Preprint also exists.

Zhou, T.; Halder, A.; Sun, Y. Fluorescent Nanosensor Based on Molecularly Imprinted Polymers Coated on Graphene Quantum Dots for Fast Detection of Antibiotics. Biosensors 2018, 8, 82. Zhou, T.; Halder, A.; Sun, Y. Fluorescent Nanosensor Based on Molecularly Imprinted Polymers Coated on Graphene Quantum Dots for Fast Detection of Antibiotics. Biosensors 2018, 8, 82.

Journal reference: Biosensors 2018, 8, 82
DOI: 10.3390/bios8030082

Abstract

In this work, we firstly explored a mild, clean, and highly efficient approach for the synthesis of graphene quantum dots (GQDs). GQDs with carboxyl groups or amino groups, were prepared from one-pot environmentally friendly method assisted by hydrogen peroxide, respectively. It was proved that carboxyl groups played an important role in the fluorescence quenching. Based on these findings, we developed a novel fluorescent nanosensor by combining molecularly imprinted polymers (MIPs) with carboxyl functionalized GQDs for the determination of tetracycline (TC) in aqueous samples. The nanocomposite was prepared using a sol-gel process. GQDs-MIPs showed strong fluorescent emission at 410 nm when excited at 360 nm, which was subsequently quenched in the presence of TC. Under optimum conditions, the fluorescence intensity of GQDs-MIPs decreased in response to the increase of TC concentration with good linearity rage of 1.0-104 µg L-1. The limit of detection was determined to be 1 µg L-1. The fluorescence intensity of GQDs-MIPs was more strongly quenched by TC compared to the corresponding non-imprinted polymers, GQDs-NIPs. With the high sensitivity, the material was also successfully worked for the detection of TC in real spiked milk samples.

Subject Areas

Graphene quantum dots, molecularly imprinted polymers, tetracycline, quenching

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