Preprint Article Version 1 This version is not peer-reviewed

Sulforaphene Isolated from Radish (Raphanus Sativus L.) Seeds Inhibits Growth of Six Cancer Cell Lines and Induces Apoptosis of A549 Cells

Version 1 : Received: 3 July 2018 / Approved: 3 July 2018 / Online: 3 July 2018 (17:26:00 CEST)

How to cite: Lim, S.; Ahn, J.; Lee, E.J.; Kim, J. Sulforaphene Isolated from Radish (Raphanus Sativus L.) Seeds Inhibits Growth of Six Cancer Cell Lines and Induces Apoptosis of A549 Cells. Preprints 2018, 2018070060 (doi: 10.20944/preprints201807.0060.v1). Lim, S.; Ahn, J.; Lee, E.J.; Kim, J. Sulforaphene Isolated from Radish (Raphanus Sativus L.) Seeds Inhibits Growth of Six Cancer Cell Lines and Induces Apoptosis of A549 Cells. Preprints 2018, 2018070060 (doi: 10.20944/preprints201807.0060.v1).

Abstract

Sulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth of six cancer cell lines (A549, CHO, HeLa, Hepa1c1c7, HT-29, and LnCaP), with relative half maximal inhibitory concentration (IC50) values ranging from 1.37 to 3.31 g/mL. Among the six cancer cell lines evaluated, SFE showed the greatest growth inhibition against A549 lung cancer cells. In A549 cells, SFE induced apoptosis via changes in the levels of poly (adenosine diphosphate ribose) polymerase and caspase-3, -8, and -9. Our results indicate that SFE from radish seeds may have significant anti-proliferative potency against a broad range of human cancer cells via induction of apoptosis.

Subject Areas

Anti-proliferation; Brassica vegetables; Human disease; Isothiocyanates; MTT assay

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