Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effect in Neuroinflammation

Paul O. Guillen
ORCID logo ,
Sandra Gegunde
,
Karla B. Jaramillo
,
Amparo Alfonso
ORCID logo ,
Kevin Calabro
ORCID logo ,
Eva Alonso
,
Jenny Rodriguez
,
Luis M. Botana
* ORCID logo ,
Olivier P. Thomas
* ORCID logo
Version 1 : Received: 1 July 2018 / Approved: 3 July 2018 / Online: 3 July 2018 (12:29:14 CEST)

A peer-reviewed article of this Preprint also exists.

Guillen, P.O.; Gegunde, S.; Jaramillo, K.B.; Alfonso, A.; Calabro, K.; Alonso, E.; Rodriguez, J.; Botana, L.M.; Thomas, O.P. Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation. Mar. Drugs 2018, 16, 242. Guillen, P.O.; Gegunde, S.; Jaramillo, K.B.; Alfonso, A.; Calabro, K.; Alonso, E.; Rodriguez, J.; Botana, L.M.; Thomas, O.P. Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation. Mar. Drugs 2018, 16, 242.

Abstract

Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Peninsula of Santa Elena – Ecuador, together with three known alkaloids zoanthamine, norzoanthamine and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds were evaluated in microglia BV-2 cells and high inhibitory effects were observed in ROS and NO generation.

Keywords

zoantharia; tropical Eastern Pacific; Zoanthus pulchellus; zoanthamine; inflammation

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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