Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Consumption of Polyphenol Rich Curry in the Polyspice Study

Sumanto Haldar
ORCID logo ,
Sze Han Lee
ORCID logo ,
Jun Jie Tan
,
Siok Ching Chia
,
Christiani Jeyakumar Henry
* ORCID logo ,
Eric Chun Yong Chan
*
Dr. S. Haldar and S. H. Lee contributed equally to this work.
Version 1 : Received: 25 June 2018 / Approved: 26 June 2018 / Online: 26 June 2018 (11:04:51 CEST)

A peer-reviewed article of this Preprint also exists.

Haldar, S.; Lee, S.H.; Tan, J.J.; Chia, S.C.; Henry, C.J.; Chan, E.C.Y. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study. Nutrients 2018, 10, 934. Haldar, S.; Lee, S.H.; Tan, J.J.; Chia, S.C.; Henry, C.J.; Chan, E.C.Y. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study. Nutrients 2018, 10, 934.

Abstract

Spices rich in polyphenols are metabolized to a convergent group of phenolic acids. We conducted a dose-exposure nutrikinetic study to investigate associations between mixed spices intake and plasma concentrations of selected, unconjugated phenolic acids. In a randomized crossover study, 20 Chinese males consumed a curry meal containing 0 g, 6 g, and 12 g of mixed spices. Postprandial blood was drawn up to 7 h at regular intervals and plasma phenolic acids were quantified via LC-MS/MS. Cinnamic acid (CNA, p < 0.0001) and phenylacetic acid (PAA, p < 0.0005) concentrations were significantly increased with mixed spices consumption, although none of the other measured phenolic acids differ significantly between treatments. CNA displayed a high dose-exposure association (R2 > 0.8, p < 0.0001). The adjusted mean AUC0-7 h for CNA during the 3 increasing doses were 8.4 ± 3.4, 376.1 ± 104.7 and 875.7 ± 291.9 nM·h respectively. Plasma CNA concentration may be used as a biomarker of spice intake.

Keywords

spices; polyphenol; phenolic acids; metabolites; nutrikinetics

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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