Preprint Article Version 1 This version is not peer-reviewed

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Consumption of Polyphenol Rich Curry in the Polyspice Study

Dr. S. Haldar and S. H. Lee contributed equally to this work.
Version 1 : Received: 25 June 2018 / Approved: 26 June 2018 / Online: 26 June 2018 (11:04:51 CEST)

A peer-reviewed article of this Preprint also exists.

Haldar, S.; Lee, S.H.; Tan, J.J.; Chia, S.C.; Henry, C.J.; Chan, E.C.Y. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study. Nutrients 2018, 10, 934. Haldar, S.; Lee, S.H.; Tan, J.J.; Chia, S.C.; Henry, C.J.; Chan, E.C.Y. Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study. Nutrients 2018, 10, 934.

Journal reference: Nutrients 2018, 10, 934
DOI: 10.3390/nu10070934

Abstract

Spices rich in polyphenols are metabolized to a convergent group of phenolic acids. We conducted a dose-exposure nutrikinetic study to investigate associations between mixed spices intake and plasma concentrations of selected, unconjugated phenolic acids. In a randomized crossover study, 20 Chinese males consumed a curry meal containing 0 g, 6 g, and 12 g of mixed spices. Postprandial blood was drawn up to 7 h at regular intervals and plasma phenolic acids were quantified via LC-MS/MS. Cinnamic acid (CNA, p < 0.0001) and phenylacetic acid (PAA, p < 0.0005) concentrations were significantly increased with mixed spices consumption, although none of the other measured phenolic acids differ significantly between treatments. CNA displayed a high dose-exposure association (R2 > 0.8, p < 0.0001). The adjusted mean AUC0-7 h for CNA during the 3 increasing doses were 8.4 ± 3.4, 376.1 ± 104.7 and 875.7 ± 291.9 nM·h respectively. Plasma CNA concentration may be used as a biomarker of spice intake.

Subject Areas

spices; polyphenol; phenolic acids; metabolites; nutrikinetics

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.