Preprint Article Version 1 This version is not peer-reviewed

Functionalized Folic Acid-Chitosan Nanoparticles for Encapsulation of Dietary Polyphenols

Version 1 : Received: 1 June 2018 / Approved: 4 June 2018 / Online: 4 June 2018 (10:41:51 CEST)

How to cite: Chanphai, P.; Tajmir-Riahi, H. Functionalized Folic Acid-Chitosan Nanoparticles for Encapsulation of Dietary Polyphenols. Preprints 2018, 2018060033 (doi: 10.20944/preprints201806.0033.v1). Chanphai, P.; Tajmir-Riahi, H. Functionalized Folic Acid-Chitosan Nanoparticles for Encapsulation of Dietary Polyphenols. Preprints 2018, 2018060033 (doi: 10.20944/preprints201806.0033.v1).

Abstract

Encapsulation of antioxidant polyphenols leads to increase solubility and bioavailability of these micronutrients in solution. The encapsulation of antioxidant resveratrol, genistein and curcumin by folic acid-chitosan nanocapsules was studied in aqueous solution, using multiple spectroscopic methods, TEM images. Structural analysis showed that polyphenol bindings are via hydrophilic, hydrophobic and H-bonding contacts with resveratrol forming more stable conjugates. As chitosan size increased, the binding efficacy and stability of polyphenol-polymer adducts were increased. Polyphenol binding induced major alterations of chitosan morphology. Chitosan nanoparticles are capable of delivery of polyphenols in vitro.

Subject Areas

polyphenols; folic acid-chitosan; encapsulation; loading efficacy; TEM

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