Preprint Article Version 1 This version is not peer-reviewed

Diversity of Gut Microbiota in Autism Reveals Differential Abundance of Prevotella and Akkermansia Species

Version 1 : Received: 23 May 2018 / Approved: 25 May 2018 / Online: 25 May 2018 (16:15:27 CEST)

How to cite: Agarwala, S.; Naik, B.; B Ramachandra, N. Diversity of Gut Microbiota in Autism Reveals Differential Abundance of Prevotella and Akkermansia Species. Preprints 2018, 2018050375 (doi: 10.20944/preprints201805.0375.v1). Agarwala, S.; Naik, B.; B Ramachandra, N. Diversity of Gut Microbiota in Autism Reveals Differential Abundance of Prevotella and Akkermansia Species. Preprints 2018, 2018050375 (doi: 10.20944/preprints201805.0375.v1).

Abstract

Background: Gut-Brain-Axis provides bidirectional communicational route; imbalance of which can have pathophysiological consequences. It is a frontier in autism research, affects 85% of autistic children (NIH report). Their microbiome has few overall microbes and smaller number of health promising microbes than their neurotypical peers. We hypothesize autism gut might play a role in manifestation of autism behaviours and on treatment, can revert back to normal behaviour considerably. The aim is to better understand to what degree gut microbiota of autism subjects differs from controls and identify bacterial species present exclusively in autism. Materials and Methods: 16s-rRNA-sequence of autism-subjects were retrieved from the American Gut Project Archive. Taxonomic assignment was inferred by similarity based methods using Quantitative Insights Into Microbial Ecology (QIIME). Species abundance was characterized and co-occurrence network was built to infer species interaction using measures of diversity. Statistical parameters were considered to validate the findings. Result: A total of 206 (1.8%) of American Gut Project datasets onstituted of autistic samples. Various bacteria such as Akkermansia sp., and Prevotella sp., were harboured in higher abundance in autistic children with statistical significance than in controls. Conclusion: These findings indicate connecting-link between gut-microbiome-brain-axis and autistic behaviour which can result in improved management

Subject Areas

autism phenome; gut microbiome; behaviour reversal; meta-analysis; 16srRNA sequencing; operational taxonomic units (OTUs)

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