Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Annexins in Translational Research: Hidden Treasures to be Found

Version 1 : Received: 22 May 2018 / Approved: 23 May 2018 / Online: 23 May 2018 (08:19:42 CEST)

How to cite: Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319. https://doi.org/10.20944/preprints201805.0319.v1 Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319. https://doi.org/10.20944/preprints201805.0319.v1

Abstract

The vertebrate annexin superfamily (AnxA) consists of 12 calcium (Ca2+) and phospholipid binding proteins which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+-controlled regulation of membrane events. In this review, we discuss several themes of potential therapeutic value, namely the regulation of the immune response and the control of tissue homeostasis, that repeatedly surface in the annexin action profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically clinical point of view.

Keywords

annexins; inflammation; wound healing; drug target; translational research

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.