Preprint Review Version 1 This version is not peer-reviewed

Annexins in Translational Research: Hidden Treasures to be Found

Version 1 : Received: 22 May 2018 / Approved: 23 May 2018 / Online: 23 May 2018 (08:19:42 CEST)

How to cite: Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319 (doi: 10.20944/preprints201805.0319.v1). Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319 (doi: 10.20944/preprints201805.0319.v1).

Abstract

The vertebrate annexin superfamily (AnxA) consists of 12 calcium (Ca2+) and phospholipid binding proteins which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+-controlled regulation of membrane events. In this review, we discuss several themes of potential therapeutic value, namely the regulation of the immune response and the control of tissue homeostasis, that repeatedly surface in the annexin action profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically clinical point of view.

Subject Areas

annexins; inflammation; wound healing; drug target; translational research

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