Preprint Article Version 1 This version is not peer-reviewed

Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source

Version 1 : Received: 16 May 2018 / Approved: 17 May 2018 / Online: 17 May 2018 (12:15:23 CEST)

How to cite: Ogiwara, Y.; Takano, K.; Horikawa, S.; Sakai, N. Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source. Preprints 2018, 2018050246 (doi: 10.20944/preprints201805.0246.v1). Ogiwara, Y.; Takano, K.; Horikawa, S.; Sakai, N. Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source. Preprints 2018, 2018050246 (doi: 10.20944/preprints201805.0246.v1).

Abstract

Indium-catalyzed reaction of lactones and a disilathiane leading to thiolactones is described. The direct synthesis of thiolactones from lactones with an appropriate sulfur source is one of the most attractive approaches in organic and pharmaceutical chemistry. In this context, we found an indium-catalyzed direct conversion of lactones into thiolactones in the presence of elemental sulfur and a hydrosilane via formation of the disilathiane in-situ. On the basis of the previous reaction, the application utilizing the disilathiane as a sulfur source was performed herein for the efficient synthesis of a variety of thiolactone derivatives from lactones by an indium-catalyst.

Subject Areas

indium-catalyst; disilathiane; lactones; thiolactones

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.