Preprint Article Version 1 This version is not peer-reviewed

Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source

Version 1 : Received: 16 May 2018 / Approved: 17 May 2018 / Online: 17 May 2018 (12:15:23 CEST)

A peer-reviewed article of this Preprint also exists.

Ogiwara, Y.; Takano, K.; Horikawa, S.; Sakai, N. Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source. Molecules 2018, 23, 1339. Ogiwara, Y.; Takano, K.; Horikawa, S.; Sakai, N. Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source. Molecules 2018, 23, 1339.

Journal reference: Molecules 2018, 23, 1339
DOI: 10.3390/molecules23061339

Abstract

Indium-catalyzed reaction of lactones and a disilathiane leading to thiolactones is described. The direct synthesis of thiolactones from lactones with an appropriate sulfur source is one of the most attractive approaches in organic and pharmaceutical chemistry. In this context, we found an indium-catalyzed direct conversion of lactones into thiolactones in the presence of elemental sulfur and a hydrosilane via formation of the disilathiane in-situ. On the basis of the previous reaction, the application utilizing the disilathiane as a sulfur source was performed herein for the efficient synthesis of a variety of thiolactone derivatives from lactones by an indium-catalyst.

Subject Areas

indium-catalyst; disilathiane; lactones; thiolactones

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