Preprint Article Version 1 This version is not peer-reviewed

Grating-coupled Surface Plasmon Resonance (GC-SPR) Optimization for Phase-interrogation Biosensing in a Microfluidic Circuit

Version 1 : Received: 27 April 2018 / Approved: 27 April 2018 / Online: 27 April 2018 (16:06:58 CEST)

A peer-reviewed article of this Preprint also exists.

Rossi, S.; Gazzola, E.; Capaldo, P.; Borile, G.; Romanato, F. Grating-Coupled Surface Plasmon Resonance (GC-SPR) Optimization for Phase-Interrogation Biosensing in a Microfluidic Chamber. Sensors 2018, 18, 1621. Rossi, S.; Gazzola, E.; Capaldo, P.; Borile, G.; Romanato, F. Grating-Coupled Surface Plasmon Resonance (GC-SPR) Optimization for Phase-Interrogation Biosensing in a Microfluidic Chamber. Sensors 2018, 18, 1621.

Journal reference: Sensors 2018, 18, 1621
DOI: 10.3390/s18051621

Abstract

Surface Plasmon Resonance (SPR) based sensors have the advantage of being label-free, enzyme-free and real-time. However, their spreading in multidisciplinary research is still limited and almost confined to prism-coupled devices. Plasmonic gratings, combined with a simple and cost-effective instrumentation, have been poorly developed compared to prism-coupled system mainly due to their lower sensitivity. Here we describe the optimization and signal enhancement of a sensing platform based on phase-interrogation method, which entails the exploitation of a nanostructured sensor. This technique is particularly suitable for integration of the plasmonic sensor in a lab-on-a-chip platform and can be used in a microfluidic circuit to ease the sensing procedures and limit the injected volume. The careful optimization of most suitable experimental parameters by numerical simulations leads to a 30 to 50% enhancement of SPR response, opening new possibilities for applications in the biomedical research field while maintaining the ease and versatility of the configuration.

Subject Areas

surface plasmon resonance; biosensing; nanofabrication; lab-on-a-chip; microfluidic

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