Preprint Article Version 1 This version is not peer-reviewed

Prenatal Exposure to Bisphenol A and Phthalates and Behavioral Problems in Children at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Version 1 : Received: 27 April 2018 / Approved: 27 April 2018 / Online: 27 April 2018 (08:27:38 CEST)

How to cite: Minatoya, M.; Itoh, S.; Yamazaki, K.; Araki, A.; Miyashita, C.; Tamura, N.; Yamamoto, J.; Onoda, Y.; Ogasawara, K.; Matsumura, T.; Kishi, R. Prenatal Exposure to Bisphenol A and Phthalates and Behavioral Problems in Children at Preschool Age: The Hokkaido Study on Environment and Children’s Health. Preprints 2018, 2018040355 (doi: 10.20944/preprints201804.0355.v1). Minatoya, M.; Itoh, S.; Yamazaki, K.; Araki, A.; Miyashita, C.; Tamura, N.; Yamamoto, J.; Onoda, Y.; Ogasawara, K.; Matsumura, T.; Kishi, R. Prenatal Exposure to Bisphenol A and Phthalates and Behavioral Problems in Children at Preschool Age: The Hokkaido Study on Environment and Children’s Health. Preprints 2018, 2018040355 (doi: 10.20944/preprints201804.0355.v1).

Abstract

Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates, however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the 1st trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order and age at SDQ completed. The median concentrations of BPA, MnBP, MiBP, MEHP and MECPP were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. BPA level was associated with increased hyperactivity/inattention risk among girls (OR=1.66, 95% CI: 0.95-2.90) and∑DBPm (MnBP + MiBP) level was associated with decreased total difficulties risk overall and among girls (OR=0.48, 95% CI: 0.20-1.13, OR=0.24, 95% CI: 0.06-1.03, respectively) without significance. MECPP level was associated with increase conduct problems risk (OR=2.78, 95% CI: 1.36-5.68). Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age, however, suggested possible association between MECPP levels and increased risk of conduct problems.

Subject Areas

SDQ; bisphenol A; phthalates; prenatal exposure; birth cohort; behavioral problems

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