Mazaafrianto, D.N.; Maeki, M.; Ishida, A.; Tani, H.; Tokeshi, M. Recent Microdevice-Based Aptamer Sensors. Micromachines2018, 9, 202.
Mazaafrianto, D.N.; Maeki, M.; Ishida, A.; Tani, H.; Tokeshi, M. Recent Microdevice-Based Aptamer Sensors. Micromachines 2018, 9, 202.
Since the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, there has been an increasing demand to develop microfluidic-based aptasensors for analytical technique applications. This review introduces the principal concepts of aptasensors and then presents some advanced applications of microdevice-based aptasensors on several platforms. Highly sensitive detection techniques such as electrochemical and optical detection have been integrated into lab-on-a-chip devices and researchers have moved towards the goal of establishing point-of-care diagnoses for target analyses.
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