Preprint Review Version 1 This version is not peer-reviewed

Recent Microdevice-based Aptamer Sensors

Version 1 : Received: 7 April 2018 / Approved: 7 April 2018 / Online: 7 April 2018 (12:10:02 CEST)

A peer-reviewed article of this Preprint also exists.

Mazaafrianto, D.N.; Maeki, M.; Ishida, A.; Tani, H.; Tokeshi, M. Recent Microdevice-Based Aptamer Sensors. Micromachines 2018, 9, 202. Mazaafrianto, D.N.; Maeki, M.; Ishida, A.; Tani, H.; Tokeshi, M. Recent Microdevice-Based Aptamer Sensors. Micromachines 2018, 9, 202.

Journal reference: Micromachines 2018, 9, 202
DOI: 10.3390/mi9050202

Abstract

Since the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, there has been an increasing demand to develop microfluidic-based aptasensors for analytical technique applications. This review introduces the principal concepts of aptasensors and then presents some advanced applications of microdevice-based aptasensors on several platforms. Highly sensitive detection techniques such as electrochemical and optical detection have been integrated into lab-on-a-chip devices and researchers have moved towards the goal of establishing point-of-care diagnoses for target analyses.

Subject Areas

microdevice; aptamer; biosensor; SELEX; lab-on-chip; point-of-care

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