Preprint Review Version 1 This version is not peer-reviewed

The Nefarious Nexus of Noncoding RNAs in Cancer

Version 1 : Received: 20 March 2018 / Approved: 21 March 2018 / Online: 21 March 2018 (07:28:25 CET)

How to cite: Anastasiadou, E.; Faggioni, A.; Trivedi, P.; Slack, F.J. The Nefarious Nexus of Noncoding RNAs in Cancer. Preprints 2018, 2018030187 (doi: 10.20944/preprints201803.0187.v1). Anastasiadou, E.; Faggioni, A.; Trivedi, P.; Slack, F.J. The Nefarious Nexus of Noncoding RNAs in Cancer. Preprints 2018, 2018030187 (doi: 10.20944/preprints201803.0187.v1).

Abstract

The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer.

Subject Areas

noncoding RNA; miRNA; lncRNA; circRNA; ncRNA network in cancer; cancer biomarkers; RNA aided cancer therapy

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