Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

# Does Glutamine Concentration Depends on the Type of the Operation?

Version 1 : Received: 6 March 2018 / Approved: 7 March 2018 / Online: 7 March 2018 (05:21:29 CET)

How to cite: Rozowicz, A.; Kusza, K.; Jakubczyk, M.; Kośliński, P.; Szatkowska-Wandas, P.; Wawrzyniak, K.; Koba, M.; Szopinski, J.; Jakubczyk, P. Does Glutamine Concentration Depends on the Type of the Operation?. Preprints 2018, 2018030051 (doi: 10.20944/preprints201803.0051.v1). Rozowicz, A.; Kusza, K.; Jakubczyk, M.; Kośliński, P.; Szatkowska-Wandas, P.; Wawrzyniak, K.; Koba, M.; Szopinski, J.; Jakubczyk, P. Does Glutamine Concentration Depends on the Type of the Operation?. Preprints 2018, 2018030051 (doi: 10.20944/preprints201803.0051.v1).

## Abstract

Glutamine is the main amino acid which is substrate for gluconeogenesis in postoperative period. It is suggested that this leads to a substantial and a long-term decline in glutamine concentration. Glutamine is a source of energy for the synthesis of nucleotides, lymphocytes and cells of gastrointestinal tract. In this study, 79 patients were qualified to a coronary artery bypass surgery (Group I) or a surgery in the large intestine area (Group II). The objectives of this study were: evaluation of the impact of surgical procedures on the serum concentration of glutamine of the operated patients, assessment of gender, weight and BMI impact on glutamine concentration and analysis of the correlation between glutaminę serum concentration and laboratory parameters. The mean concentration of glutamine before surgery, the 3rd and 5th day after surgery was higher in Group I. CRP level in the 3rd and 5th postoperative day was higher in Group II. There were no significant differences betweengroups when it comes to BMI and the concentration of CRP (p <0.05). Glutamine concentration depends on the severity of inflammation, the operated body cavity and the intensified catabolism which results from different pathophysiology of digestive system diseases and coronary arterial disease.

## Keywords

glutamine; perioperative period; bypass surgery; intestine surgery; HPLC

## Subject

MEDICINE & PHARMACOLOGY, Nutrition

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