Preprint Review Version 1 This version is not peer-reviewed

Alcoholism: A Multi-Systemic Molecular Insult to Organ Damage

Version 1 : Received: 19 February 2018 / Approved: 19 February 2018 / Online: 19 February 2018 (14:30:39 CET)

A peer-reviewed article of this Preprint also exists.

Dguzeh, U.; Haddad, N.C.; Smith, K.T.S.; Johnson, J.O.; Doye, A.A.; Gwathmey, J.K.; Haddad, G.E. Alcoholism: A Multi-Systemic Cellular Insult to Organs. Int. J. Environ. Res. Public Health 2018, 15, 1083. Dguzeh, U.; Haddad, N.C.; Smith, K.T.S.; Johnson, J.O.; Doye, A.A.; Gwathmey, J.K.; Haddad, G.E. Alcoholism: A Multi-Systemic Cellular Insult to Organs. Int. J. Environ. Res. Public Health 2018, 15, 1083.

Journal reference: Int. J. Environ. Res. Public Health 2018, 15, 1083
DOI: 10.3390/ijerph15061083

Abstract

Alcohol abuse can result in detrimental multisystem effects. Chronic alcohol abuse is known to be associated with pathophysiological changes in multiple organs often resulting in life threatening clinical outcomes e.g. breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, alcohol-induced cardiomyopathy and heart failure as well as central nervous system disorders. In this review article, we will discuss the multisystemic effects of alcohol abuse and explore in greater detail alcohol’s impact on two main systems that result in pathophysiological changes i.e. the cardiovascular and central nervous systems.

Subject Areas

Alcohol abuse, Alcohol beneficial effects, multi-organ effects of alcohol

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