Preprint Article Version 1 This version is not peer-reviewed

Examining the Causal Link between and Air Pollution, Tuberculosis Type 2 Diabetes Mellitus

Version 1 : Received: 10 January 2018 / Approved: 11 January 2018 / Online: 11 January 2018 (01:45:36 CET)

How to cite: Bhatter, P.; Mistry, N. Examining the Causal Link between and Air Pollution, Tuberculosis Type 2 Diabetes Mellitus. Preprints 2018, 2018010095 (doi: 10.20944/preprints201801.0095.v1). Bhatter, P.; Mistry, N. Examining the Causal Link between and Air Pollution, Tuberculosis Type 2 Diabetes Mellitus. Preprints 2018, 2018010095 (doi: 10.20944/preprints201801.0095.v1).

Abstract

Rapid urbanization, increasing population and increased industrialization to cater to demands of the growing population has imposed upon us a huge environmental cost. The significantly deteriorated air quality across the globe is associated with a direct and indirect impact on public health. While associated disorders such as chronic obstructive pulmonary diseases, heart failures are well documented, less is known about the biological basis of the process. We hypothesize that the worsening air quality may likely impact common systemic inflammatory processes, thus driving communicable and non-communicable diseases alike.Receptor mediated entry of particulate matter (PM2.5) results in activation of signaling cascades which culminate in production of inflammatory chemokine and cytokine responses, traversing through the blood mediating impacting not only on other organs but also dysbiosis of microflora. For the purpose of the review we choose tuberculosis (TB) as a model for communicable infectious disease and type 2 diabetes mellitus (T2DM) as a marker for non-communicable disorder.  The increasing prevalence of these co-morbidities and the burdening of public health systems justifies this example. However the hypothesis may be applicable to other inflammation driven disorders also.

Subject Areas

Tuberculosis; Type 2; diabetes mellitus PM2.5; air pollution; inflammation

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