Preprint
Short Note
5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene – Synthesis and Preliminary Cytotoxic Screning
This version is not peer-reviewed.
Submitted:
22 December 2017
Posted:
25 December 2017
You are already at the latest version
A peer-reviewed article of this preprint also exists.
Abstract
5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene was obtained in a condensation reaction of 2-amino-5-bromobenzohydrazide and methylphosphonyl dichloride in the presence of triethylamine. An initial biological screening was performed for the obtained product. The synthesized compound possesses two aromatic primary amine groups and two bromine atoms within the structure, which are suitable for further structural modifications.
Keywords:
aromatic hydrazide condensation
; phosphorus heterocycles
; cytotoxicity
; supplementary.pdf (527.85KB )
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Downloads
479
Views
487
Comments
0
Subscription
Notify me about updates to this article or when a peer-reviewed version is published.
MDPI Initiatives
Important Links
© 2025 MDPI (Basel, Switzerland) unless otherwise stated