Preprint Short Note Version 1 This version not peer reviewed

5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene – Synthesis and Preliminary Cytotoxic Screning

Version 1 : Received: 22 December 2017 / Approved: 25 December 2017 / Online: 25 December 2017 (07:00:47 CET)

A peer-reviewed article of this Preprint also exists.

Kasperowicz, S.; Czerwińska, J.; Majchrzak, B.; Tudek, B.; Mieczkowski, A. 5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene. Molbank 2018, 2018, M978. Kasperowicz, S.; Czerwińska, J.; Majchrzak, B.; Tudek, B.; Mieczkowski, A. 5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene. Molbank 2018, 2018, M978.

Journal reference: Molbank 2018, 2018, M978
DOI: 10.3390/M978

Abstract

5-Methyl-3,8-di-(2-amino-4-bromophenyl)-4,9-dioxa-1,2,6,7-tetraaza-5λ5-phosphaspiro[4.4]nona-2,7-diene was obtained in a condensation reaction of 2-amino-5-bromobenzohydrazide and methylphosphonyl dichloride in the presence of triethylamine. An initial biological screening was performed for the obtained product. The synthesized compound possesses two aromatic primary amine groups and two bromine atoms within the structure, which are suitable for further structural modifications.

Subject Areas

aromatic hydrazide condensation; phosphorus heterocycles; cytotoxicity;

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