Does Irisin Link Physical Exercise with Alzheimer’s Disease?

Dewan Md. Sumsuzzman; Yunho Jin; Yonggeun Hong

doi:10.20944/preprints201712.0023.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 3 December 2017 / Approved: 4 December 2017 / Online: 4 December 2017 (08:46:17 CET)
Version 2 : Received: 9 February 2018 / Approved: 11 February 2018 / Online: 11 February 2018 (04:28:07 CET)

The skeletal muscle-secreted myokine irisin, which is produced in response to physical exercise, has several protective functions both in the central and peripheral nervous systems, including regulation of brain-derived neurotrophic factor, modification of telomere length, inhibition of the endoplasmic reticulum stress response, and anti-inflammatory and anti-apoptotic effects that may be of benefit in neurodegenerative diseases such as Alzheimer’s disease (AD). The present review is based on the hypothesis that irisin connects physical exercise with AD progression. We herein describe current knowledge of the physiology of irisin and its potential role in AD. We conclude that, although current and ongoing research on irisin is very promising, further research is required to clarify its potential as a meaningful target for drugs to treat human diseases.

physical exercise; irisin; neurodegeneration; aging; Alzheimer’s disease

Comment 1

Received: 14 December 2017
Commenter: Farhad Hossain
The commenter has declared there is no conflict of interests.

Comment: I strongly believe that the reader of this article can find the novel molecular mechanism of aging. Herein, the reader can also understand the current knowledge of the physiology of irisin and its potential role in Alzheimer’s disease (AD). Finally, I hope this article would also greatly impact on the scientific community.

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Does Irisin Link Physical Exercise with Alzheimer’s Disease?

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