Does Irisin Link Physical Exercise with Alzheimer&rsquo;s Disease?

Dewan Md. Sumsuzzman; Yunho Jin; Yonggeun Hong

doi:10.20944/preprints201712.0023.v1

Preprint Review Version 1 This version is not peer-reviewed

Does Irisin Link Physical Exercise with Alzheimer’s Disease?

Dewan Md. Sumsuzzman ,

Yunho Jin ,

Yonggeun Hong ^*

Version 1 : Received: 3 December 2017 / Approved: 4 December 2017 / Online: 4 December 2017 (08:46:17 CET)
Version 2 : Received: 9 February 2018 / Approved: 11 February 2018 / Online: 11 February 2018 (04:28:07 CET)

How to cite: Sumsuzzman, D.M.; Jin, Y.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v1). Sumsuzzman, D.M.; Jin, Y.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v1).

Abstract

The skeletal muscle-secreted myokine irisin, which is produced in response to physical exercise, has several protective functions both in the central and peripheral nervous systems, including regulation of brain-derived neurotrophic factor, modification of telomere length, inhibition of the endoplasmic reticulum stress response, and anti-inflammatory and anti-apoptotic effects that may be of benefit in neurodegenerative diseases such as Alzheimer’s disease (AD). The present review is based on the hypothesis that irisin connects physical exercise with AD progression. We herein describe current knowledge of the physiology of irisin and its potential role in AD. We conclude that, although current and ongoing research on irisin is very promising, further research is required to clarify its potential as a meaningful target for drugs to treat human diseases.

Subject Areas

physical exercise; irisin; neurodegeneration; aging; Alzheimer’s disease

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (1)

Importance: How significant is the paper to the field?

Outstanding/highlight paper		100%
Significant contribution		0%
Incremental contribution		0%
No contribution		0%

Soundness of evidence/arguments presented:

Conclusions well supported		100%
Most conclusions supported (minor revision needed)		0%
Incomplete evidence (major revision needed)		0%
Hypothesis, unsupported conclusions, or proof-of-principle		0%

Comment 1

Received: 14 December 2017
Commenter: Farhad Hossain
The commenter has declared there is no conflict of interests.

Comment: I strongly believe that the reader of this article can find the novel molecular mechanism of aging. Herein, the reader can also understand the current knowledge of the physiology of irisin and its potential role in Alzheimer’s disease (AD). Finally, I hope this article would also greatly impact on the scientific community.

+ Respond to this comment

Your full name

Your affiliation information (e.g., name of your university/institution/organization)

Not displayed online.

Your Email address (not made public)

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website I want to get recognition for my comment on Publons

[what’s this?]. Link your accounts here

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)

Get PDF Cite Share

Bookmark BibSonomy Mendeley Reddit Delicious Publons

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.