Preprint Review Version 1 This version not peer reviewed

Intra- and Intercellular Quality Control Mechanisms of Mitochondria

Version 1 : Received: 1 December 2017 / Approved: 1 December 2017 / Online: 1 December 2017 (13:55:15 CET)

A peer-reviewed article of this Preprint also exists.

Kiriyama, Y.; Nochi, H. Intra- and Intercellular Quality Control Mechanisms of Mitochondria. Cells 2018, 7, 1. Kiriyama, Y.; Nochi, H. Intra- and Intercellular Quality Control Mechanisms of Mitochondria. Cells 2018, 7, 1.

Journal reference: Cells 2018, 7, 1
DOI: 10.3390/cells7010001

Abstract

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.

Subject Areas

mitochondria; mitophagy; transmitophgy; PGC1; mitofusin; DRP1; MIRO1; CD38

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