Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Phytotherapy in the Management of Diabetes: A Review

Paolo Governa
* ORCID logo ,
Giulia Baini
,
Vittoria Borgonetti
,
Giulia Cettolin
,
Daniela Giachetti
,
Anna Rosa Magnano
,
Elisabetta Miraldi
,
Marco Biagi
ORCID logo
Version 1 : Received: 29 November 2017 / Approved: 30 November 2017 / Online: 30 November 2017 (08:37:03 CET)
Version 2 : Received: 30 December 2017 / Approved: 31 December 2017 / Online: 31 December 2017 (03:36:25 CET)

A peer-reviewed article of this Preprint also exists.

Governa, P.; Baini, G.; Borgonetti, V.; Cettolin, G.; Giachetti, D.; Magnano, A.R.; Miraldi, E.; Biagi, M. Phytotherapy in the Management of Diabetes: A Review. Molecules 2018, 23, 105. Governa, P.; Baini, G.; Borgonetti, V.; Cettolin, G.; Giachetti, D.; Magnano, A.R.; Miraldi, E.; Biagi, M. Phytotherapy in the Management of Diabetes: A Review. Molecules 2018, 23, 105.

Abstract

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity.Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.

Keywords

phytotherapy; hyperglycemia; diabetes; medicinal plants

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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