Preprint Review Version 1 This version is not peer-reviewed

Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover

Version 1 : Received: 27 November 2017 / Approved: 27 November 2017 / Online: 27 November 2017 (09:18:27 CET)

A peer-reviewed article of this Preprint also exists.

Ali, S.; McStay, G.P. Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover. Antioxidants 2018, 7, 15. Ali, S.; McStay, G.P. Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover. Antioxidants 2018, 7, 15.

Journal reference: Antioxidants 2018, 7, 15
DOI: 10.3390/antiox7010015

Abstract

The mitochondrial network is a dynamic organization within eukaryotic cells that participates in a variety of essential cellular processes, such as ATP synthesis, central metabolism, apoptosis and inflammation. The mitochondrial network is balanced between rates of fusion and fission that respond to pathophysiologic signals to coordinate appropriate mitochondrial processes. Mitochondrial fusion and fission are regulated by proteins that either reside or translocate to the inner or outer mitochondrial membranes or are soluble in the inter-membrane space. Mitochondrial fission and fusion are performed by GTPases on the outer and inner mitochondrial membranes with the assistance of other mitochondrial proteins. Due to the essential nature of mitochondrial function for cellular homeostasis regulation of mitochondrial dynamics is under strict control. Some of the mechanisms used to regulate the function of these proteins are post-translational proteolysis and/or turnover and this review will discuss these mechanisms required for correct mitochondrial network organization.

Subject Areas

mitochondria; proteolysis; protein half-life; ubiquitin

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