Preprint Review Version 1 This version is not peer-reviewed

Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2

Version 1 : Received: 31 October 2017 / Approved: 1 November 2017 / Online: 1 November 2017 (05:05:31 CET)

A peer-reviewed article of this Preprint also exists.

Campos, S.K. Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. Viruses 2017, 9, 370. Campos, S.K. Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. Viruses 2017, 9, 370.

Journal reference: Viruses 2017, 9, 370
DOI: 10.3390/v9120370

Abstract

Beginning in 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell nucleus, relying on a myriad of host cell proteins and processes. The major breakthrough finding from these recent endeavors was the realization of L2-dependent utilization of cellular sorting factors for the retrograde transport of vDNA away from degradative endo/lysosomal compartments to the Golgi, prior to mitosis-dependent nuclear accumulation of L2/vDNA. An overview of current models of HPV entry, subcellular trafficking, and the role of L2 during initial infection is provided below, highlighting unresolved questions and gaps in knowledge.

Subject Areas

human papillomavirus; HPV16; L2; subcellular trafficking; mitosis; transmembrane domain; translocation; membrane penetration; toxin; fusion peptide; gamma secretase; retromer

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