Preprint Article Version 1 This version not peer reviewed

New Cassane Diterpenoids from Caesalpinia sappan and Their Antiplasmodial Activity

Version 1 : Received: 13 October 2017 / Approved: 13 October 2017 / Online: 13 October 2017 (06:30:04 CEST)

A peer-reviewed article of this Preprint also exists.

Zhu, N.-L.; Sun, Z.-H.; Hu, M.-G.; Wu, T.-Y.; Yuan, J.-Q.; Wu, H.-F.; Tian, Y.; Li, P.-F.; Yang, J.-S.; Ma, G.-X.; Xu, X.-D. New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity. Molecules 2017, 22, 1751. Zhu, N.-L.; Sun, Z.-H.; Hu, M.-G.; Wu, T.-Y.; Yuan, J.-Q.; Wu, H.-F.; Tian, Y.; Li, P.-F.; Yang, J.-S.; Ma, G.-X.; Xu, X.-D. New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity. Molecules 2017, 22, 1751.

Journal reference: Molecules 2017, 22, 1751
DOI: 10.3390/molecules22101751

Abstract

One new cassane diterpene possessing an unusual N bridge between C-19 and C-20 named caesalsappanin R (1), as well as another new diterpene caesalsappanin S (2), were isolated from the seeds of Caesalpinia sappan with methanol extract. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Their biological activities were profiled by their antiplasmodial activity.

Subject Areas

Caesalpinia sappan; cassane diterpenes; N bridge; antimalarial activity

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