Fels, U.; Gevaert, K.; Van Damme, P. Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective. Proteomes2017, 5, 26.
Fels, U.; Gevaert, K.; Van Damme, P. Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective. Proteomes 2017, 5, 26.
Fels, U.; Gevaert, K.; Van Damme, P. Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective. Proteomes2017, 5, 26.
Fels, U.; Gevaert, K.; Van Damme, P. Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective. Proteomes 2017, 5, 26.
Abstract
By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of omics approaches to study bacterial pathogenesis. Besides, we review different omics strategies (i.e. transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
31 August 2017
Commenter:
Biswapriya B. Misra
The commenter has declared there is no conflict of interests.
Comment:
Nice one!
However, reads "omics" in the title- but fails to mention examples of "metabolomics" which is so close to the genotype- and in interactions! Unsure if sufficient examples could not be retrieved! But potential applications may be discussed.
: )
The commenter has declared there is no conflict of interests.
Comment:
We absolutely agree with your comment and should not have used the general term 'omics' in the title as metabolomics for sure relates to this matter. While we will mention potential (future) endeavors in the field of metabolomics in a subsequent version of our manuscript, we will consider adjusting the title to the following; 'Proteogenomics' in Aid of Host-pathogen Interaction Studies: A Bacterial Perspective'.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Commenter: Biswapriya B. Misra
The commenter has declared there is no conflict of interests.
However, reads "omics" in the title- but fails to mention examples of "metabolomics" which is so close to the genotype- and in interactions! Unsure if sufficient examples could not be retrieved! But potential applications may be discussed.
: )
Commenter:
The commenter has declared there is no conflict of interests.