PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association
Version 1
: Received: 27 July 2017 / Approved: 28 July 2017 / Online: 28 July 2017 (12:20:23 CEST)
How to cite:
De Vecchis, R.D.V.; Ariano, C.; Cesaro, A.; Di Biase, G. Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints2017, 2017070082. https://doi.org/10.20944/preprints201707.0082.v1
De Vecchis, R.D.V.; Ariano, C.; Cesaro, A.; Di Biase, G. Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints 2017, 2017070082. https://doi.org/10.20944/preprints201707.0082.v1
De Vecchis, R.D.V.; Ariano, C.; Cesaro, A.; Di Biase, G. Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints2017, 2017070082. https://doi.org/10.20944/preprints201707.0082.v1
APA Style
De Vecchis, R.D.V., Ariano, C., Cesaro, A., & Di Biase, G. (2017). Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints. https://doi.org/10.20944/preprints201707.0082.v1
Chicago/Turabian Style
De Vecchis, R.D.V., Arturo Cesaro and Giuseppina Di Biase. 2017 "Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association" Preprints. https://doi.org/10.20944/preprints201707.0082.v1
Abstract
An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study (Am J Med. 2016 Dec; 129(12):1299-1306). However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs , as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i.e. furosemide and similar drugs . The purpose of this retrospective study is to attempt to clarify whether regular use of thiazide diuretics as antihypertensive therapeutics is associated with a significantly increased risk of osteoporotic fractures in female patients, aged over 70 years.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
