Preprint Article Version 1 This version is not peer-reviewed

Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association

Version 1 : Received: 27 July 2017 / Approved: 28 July 2017 / Online: 28 July 2017 (12:20:23 CEST)

How to cite: De Vecchis, R.D.V.; Ariano, C.; Cesaro, A.; Di Biase, G. Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints 2017, 2017070082 (doi: 10.20944/preprints201707.0082.v1). De Vecchis, R.D.V.; Ariano, C.; Cesaro, A.; Di Biase, G. Chronic antihypertensive therapy with thiazide diuretics in older women and risk of osteoporotic vertebral fractures: A recently much-debated association. Preprints 2017, 2017070082 (doi: 10.20944/preprints201707.0082.v1).

Abstract

An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study (Am J Med. 2016 Dec; 129(12):1299-1306). However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs , as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i.e. furosemide and similar drugs . The purpose of this retrospective study is to attempt to clarify whether regular use of thiazide diuretics as antihypertensive therapeutics is associated with a significantly increased risk of osteoporotic fractures in female patients, aged over 70 years.

Subject Areas

thiazide diuretics; cardiovascular risk; osteoporosis; vertebral fractures

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