Niu, S.; Zhou, T.-T.; Xie, C.-L.; Zhang, G.-Y.; Yang, X.-W. Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207. Mar. Drugs2017, 15, 230.
Niu, S.; Zhou, T.-T.; Xie, C.-L.; Zhang, G.-Y.; Yang, X.-W. Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207. Mar. Drugs 2017, 15, 230.
Niu, S.; Zhou, T.-T.; Xie, C.-L.; Zhang, G.-Y.; Yang, X.-W. Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207. Mar. Drugs2017, 15, 230.
Niu, S.; Zhou, T.-T.; Xie, C.-L.; Zhang, G.-Y.; Yang, X.-W. Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207. Mar. Drugs 2017, 15, 230.
Abstract
A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the 1H, 13C, HSQC, COSY, HMBC, HRESIMS, and CD data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. Noteworthily, 1 is the second example of a saturated indole isolated from nature.
Chemistry and Materials Science, Medicinal Chemistry
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