Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete <em>Microbacterium </em>sp. MCCC 1A11207

Siwen Niu; Ting-Ting Zhou; Chun-Lan Xie; Gai-Yun Zhang; Xian-Wen Yang

doi:10.20944/preprints201706.0074.v1

Submitted:

14 June 2017

Posted:

16 June 2017

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Communication

This version is not peer-reviewed.

Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

Siwen Niu

,Ting-Ting Zhou,Chun-Lan Xie,Gai-Yun Zhang,Xian-Wen Yang^*

Siwen Niu

,Ting-Ting Zhou,Chun-Lan Xie,Gai-Yun Zhang,Xian-Wen Yang^*

A peer-reviewed article of this preprint also exists.

Submitted:

14 June 2017

Posted:

16 June 2017

You are already at the latest version

Abstract

A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the ¹H, ¹³C, HSQC, COSY, HMBC, HRESIMS, and CD data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. Noteworthily, 1 is the second example of a saturated indole isolated from nature.

Keywords:

deep-sea

;

actinomycete

;

Microbacterium sp.

;

indole

Subject:

Chemistry and Materials Science - Medicinal Chemistry

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