Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression

Lucia Corrado
,
Fabiola De Marchi
,
Sara Tunesi
,
Gaia Oggioni
,
Miryam Carecchio
,
Luca Magistrelli
,
Silvana Tesei
,
Giulio Riboldazzi
,
Alessio Di Fonzo
,
Clarissa Locci
,
Ilaria Trezzi
,
Roberta Zangaglia
,
Cristina Cereda
,
Sandra D'Alfonso
,
Corrado Magnani
,
Comi Giacomo Pietro
,
Giorgio Bono
,
Claudio Pacchetti
,
Roberto Cantello
,
Stefano Goldwurm
,
Cristoforo Comi
* ORCID logo
Version 1 : Received: 5 June 2017 / Approved: 6 June 2017 / Online: 6 June 2017 (08:39:30 CEST)

How to cite: Corrado, L.; De Marchi, F.; Tunesi, S.; Oggioni, G.; Carecchio, M.; Magistrelli, L.; Tesei, S.; Riboldazzi, G.; Di Fonzo, A.; Locci, C.; Trezzi, I.; Zangaglia, R.; Cereda, C.; D'Alfonso, S.; Magnani, C.; Giacomo Pietro, C.; Bono, G.; Pacchetti, C.; Cantello, R.; Goldwurm, S.; Comi, C. The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression. Preprints 2017, 2017060034. https://doi.org/10.20944/preprints201706.0034.v1 Corrado, L.; De Marchi, F.; Tunesi, S.; Oggioni, G.; Carecchio, M.; Magistrelli, L.; Tesei, S.; Riboldazzi, G.; Di Fonzo, A.; Locci, C.; Trezzi, I.; Zangaglia, R.; Cereda, C.; D'Alfonso, S.; Magnani, C.; Giacomo Pietro, C.; Bono, G.; Pacchetti, C.; Cantello, R.; Goldwurm, S.; Comi, C. The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression. Preprints 2017, 2017060034. https://doi.org/10.20944/preprints201706.0034.v1

Abstract

α-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial PD. A previous study showed that a variant of α-synuclein gene (SNCA), namely the 263bp allele of Rep1 was associated to faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in Parkinson’s Disease (PD) patients. We recruited and genotyped for SNCA-Rep1 426 PD patients with age at onset ≥40 years and disease duration ≥4 years. We then analyzed frequency and time of occurrence of wearing-off, dyskinesia, freezing of gait, visual hallucinations and dementia. SNCA Rep1 263 carriers showed increased risk of both dementia (HR=3.03) and visual hallucinations (HR=2.69) compared to 263 non-carriers. In conclusion, SNCA Rep 1 263 allele is associated to a worst cognitive outcome in PD.

Keywords

dementia; hallucinations; genetics

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.