Preprint Article Version 1 This version not peer reviewed

Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Version 1 : Received: 27 April 2017 / Approved: 27 April 2017 / Online: 27 April 2017 (04:13:10 CEST)

How to cite: Zanchet, B.; Gomes, D.B.; Corralo, V.S.; Diel, K.A.P.; Schönell, A.P.; Faust, C.; Nicola, P.; Muller, L.G.; Zanatta, A.P.; Wildner, S.M.; Bevilaqua, F.; Chitolina, R.; Sachett, A.; Zanatta, L.; Duarte, M.M.M.F.; Conterato, G.M.M.; Rocha, C.Q.; Peretti, C.; Brumelhaus, T.; Alves, N.S.; Menegatt, J.C.O.; Conte, F.; Serena, G.; Ramos, A.T.; Zimermann, F.C.; Roman Junior, W.A. Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats. Preprints 2017, 2017040179 (doi: 10.20944/preprints201704.0179.v1). Zanchet, B.; Gomes, D.B.; Corralo, V.S.; Diel, K.A.P.; Schönell, A.P.; Faust, C.; Nicola, P.; Muller, L.G.; Zanatta, A.P.; Wildner, S.M.; Bevilaqua, F.; Chitolina, R.; Sachett, A.; Zanatta, L.; Duarte, M.M.M.F.; Conterato, G.M.M.; Rocha, C.Q.; Peretti, C.; Brumelhaus, T.; Alves, N.S.; Menegatt, J.C.O.; Conte, F.; Serena, G.; Ramos, A.T.; Zimermann, F.C.; Roman Junior, W.A. Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats. Preprints 2017, 2017040179 (doi: 10.20944/preprints201704.0179.v1).

Abstract

Celtis iguanaea is popularly used in the treatment of diabetes mellitus. However, thorough chemical and pharmacological investigations regarding its activity are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea (CI) on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with CI (150, 300, or 600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day for 30 days along with a hypercholesterolemic diet. A control group (C) was given saline solution. CI showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, IL-1, IL-6, TNF-α, and IFN-γ when compared to group C (p ˂ 0.05). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI 600), maltase (CI 150, CI 300), and an increase in muscle glycogen levels (CI 300). Antioxidant effects were observed in plasma, and the histopathological analysis showed a significant decrease in the liver fat area for CI compared to group C (p < 0.001). Our results suggest that the biological effects of CI could be related to the presence of flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.

Subject Areas

medicinal plants; flavonoids; hypoglycemic; hypolipidemic; antiatherogenic

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