Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Barbara Zanchet; Denise B. Gomes; Vanessa S. Corralo; Kriptsan A. P. Diel; Amanda P. Schönell; Caroline Faust; Patrícia Nicola; Liz G. Muller; Ana Paula Zanatta; Silvana M. Wildner; Fernanda Bevilaqua; Rafael Chitolina; Adrieli Sachett; Leila Zanatta; Marta M. M. F. Duarte; Greicy M. M. Conterato; Claudia Q. Rocha; Camile Peretti; Tatiane Brumelhaus; Nayara Souza Alves; Jean Carlo Olivo Menegatt; Fernanda Conte; Guilherme Serena; Adriano Tony Ramos; Francielli Cordeiro Zimermann; Walter A. Roman Junior

doi:10.20944/preprints201704.0179.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 27 April 2017 / Approved: 27 April 2017 / Online: 27 April 2017 (04:13:10 CEST)

Celtis iguanaea is popularly used in the treatment of diabetes mellitus. However, thorough chemical and pharmacological investigations regarding its activity are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea (CI) on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with CI (150, 300, or 600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day for 30 days along with a hypercholesterolemic diet. A control group (C) was given saline solution. CI showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, IL-1, IL-6, TNF-α, and IFN-γ when compared to group C (p ˂ 0.05). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI 600), maltase (CI 150, CI 300), and an increase in muscle glycogen levels (CI 300). Antioxidant effects were observed in plasma, and the histopathological analysis showed a significant decrease in the liver fat area for CI compared to group C (p < 0.001). Our results suggest that the biological effects of CI could be related to the presence of flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.

medicinal plants; flavonoids; hypoglycemic; hypolipidemic; antiatherogenic

Medicine and Pharmacology, Pharmacology and Toxicology

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Effects of Hydroalcoholic Extract of Celtis iguanaea on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

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