Preprint Review Version 1 This version not peer reviewed

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

Version 1 : Received: 8 December 2016 / Approved: 8 December 2016 / Online: 8 December 2016 (10:24:43 CET)

A peer-reviewed article of this Preprint also exists.

Li, Y.; Li, J.; Zhou, K.; He, J.; Cao, J.; An, M.; Chang, Y.-X. A Review on Phytochemistry and Pharmacology of Cortex Periplocae. Molecules 2016, 21, 1702. Li, Y.; Li, J.; Zhou, K.; He, J.; Cao, J.; An, M.; Chang, Y.-X. A Review on Phytochemistry and Pharmacology of Cortex Periplocae. Molecules 2016, 21, 1702.

Journal reference: Molecules 2016, 21, 1702
DOI: 10.3390/molecules21121702

Abstract

Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

Subject Areas

Cortex Periplocae; traditional Chinese medicines; periplocin; phytochemistry; biological activities

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