Preprint Article Version 1 This version is not peer-reviewed

Anti-inflammatory Activity of Sanghuangporus sanghuang Mycelium

Version 1 : Received: 7 December 2016 / Approved: 7 December 2016 / Online: 7 December 2016 (11:15:30 CET)

A peer-reviewed article of this Preprint also exists.

Lin, W.-C.; Deng, J.-S.; Huang, S.-S.; Wu, S.-H.; Chen, C.-C.; Lin, W.-R.; Lin, H.-Y.; Huang, G.-J. Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. Int. J. Mol. Sci. 2017, 18, 347. Lin, W.-C.; Deng, J.-S.; Huang, S.-S.; Wu, S.-H.; Chen, C.-C.; Lin, W.-R.; Lin, H.-Y.; Huang, G.-J. Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. Int. J. Mol. Sci. 2017, 18, 347.

Journal reference: Int. J. Mol. Sci. 2017, 18, 347
DOI: 10.3390/ijms18020347

Abstract

Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with LPS-induced ALI in mice and to investigate its possible mechanism of action. The experimental results showed that the administration of SS-1 could inhibit LPS-induced inflammation. SS-1 could reduce the number of inflammatory cells, inhibit MPO activity, regulate the TLR4/PI3K/Akt/mTOR pathway and the signal transduction of NF-κB and MAPK pathways in the lung tissue, and inhibit HNGB1 activity in BALF. In addition, SS-1 could affect the synthesis of antioxidant enzymes HO-1 and Trx-1 in the lung tissue and regulate signal transduction in the KAP1/Nrf2/Keap1 pathway. Histological results showed that administration of SS-1 prior to induction could inhibit the large-scale LPS-induced neutrophil infiltration of the lung tissue. Therefore, based on all experimental results, we propose that SS-1 exhibits a protective effect against LPS-induced (ALI) in mice. The mycelium of S. sanghuang can potentially be used for the treatment or prevention of inflammation-related diseases

Subject Areas

acute lung injury; mycelium of Sanghuangporus sanghuang; lipopolysaccharide; KAP1/Nrf2 pathway; PI3K/Akt/mTOR pathways; HO-1; HNGB1

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