Version 1
: Received: 1 November 2016 / Approved: 2 November 2016 / Online: 2 November 2016 (06:58:53 CET)
How to cite:
Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints.org2016, 2016110015. https://doi.org/10.20944/preprints201611.0015.v1
Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints.org 2016, 2016110015. https://doi.org/10.20944/preprints201611.0015.v1
Cite as:
Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints.org2016, 2016110015. https://doi.org/10.20944/preprints201611.0015.v1
Khokhlova, A.; Vikulova, N.; Katsnelson, L.; Iribe, G.; Solovyova, O. Transmural Cellular Heterogeneity in Myocardial Electromechanics. Preprints.org 2016, 2016110015. https://doi.org/10.20944/preprints201611.0015.v1
Abstract
Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the action potential and contraction of the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes via cooperative mechanisms of mechano-calcium-electric feedback are essential to produce the differences in Ca2+transients and contraction profiles and may further enhance transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in afterload than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
