Preprint Article Version 1 NOT YET PEER-REVIEWED

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Version 1 : Received: 31 October 2016 / Approved: 1 November 2016 / Online: 1 November 2016 (06:54:40 CET)

A peer-reviewed article of this Preprint also exists.

Shayan, M.; Jankowitz, B.T.; Shridhar, P.; Chun, Y. Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection. J. Funct. Biomater. 2016, 7, 34. Shayan, M.; Jankowitz, B.T.; Shridhar, P.; Chun, Y. Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection. J. Funct. Biomater. 2016, 7, 34.

Journal reference: J. Funct. Biomater. 2016, 7, 34
DOI: 10.3390/jfb7040034

Abstract

Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70-96% during 30min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance specifically on the diamond-shape M-TFN with the dimensions of 145µm×20µm and a porosity of 32%. Future studies will require in-vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting.

Subject Areas

thin film nitinol; carotid artery; micro mesh stent; micropatterning

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