Preprint
Article

Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes

This version is not peer-reviewed.

Submitted:

26 October 2016

Posted:

27 October 2016

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Abstract
Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method as well as fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents.
Keywords: 
tissue-like phantoms; dual-modal imaging; fluorescence lifetime (FLT); FLT imaging (FLIM); diffusion reflection
Subject: 
Physical Sciences  -   Optics and Photonics
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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