Preprint Article Version 1 NOT YET PEER-REVIEWED

Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolyte

Version 1 : Received: 26 September 2016 / Approved: 26 September 2016 / Online: 26 September 2016 (11:47:18 CEST)

A peer-reviewed article of this Preprint also exists.

Rachmawati, H.; Rahma, A.; Al Shaal, L.; Müller, R.H.; Keck, C.M. Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes. Sci. Pharm. 2016, 84, 685-693. Rachmawati, H.; Rahma, A.; Al Shaal, L.; Müller, R.H.; Keck, C.M. Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes. Sci. Pharm. 2016, 84, 685-693.

Journal reference: Sci. Pharm. 2016, 84, 685
DOI: 10.3390/scipharm84040685

Abstract

We have successfully developed curcumin nanosuspension aimed for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) has shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of target site of the drug.

Subject Areas

curcumin; nanosuspension; electrolyte; particle aggregation; stabilizer; ionic surfactant

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