Article
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This version is not peer-reviewed
Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis
Ashutosh Pathak
Version 1
: Received: 8 September 2016 / Approved: 9 September 2016 / Online: 9 September 2016 (07:44:48 CEST)
A peer-reviewed article of this Preprint also exists.
Pathak, A.; Upreti, D.K.; Dikshit, A. Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis. Medicines 2016, 3, 24. Pathak, A.; Upreti, D.K.; Dikshit, A. Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis. Medicines 2016, 3, 24.
Journal reference: Medicines 2016, 3, 24
DOI: 10.3390/medicines3030024
Abstract
In the present study, the new biological sources in the form of lichen Usnea orientalis Motyka was screened for its antidermatophytic potential. Six species of dermatophytes were chosen on the basis of their prevalence for antidermatophytic assays, and the Clinical Laboratory Standard Institute (CLSI)-recommended broth microdilution procedure was used to detect the efficacy of extract against dermatophytes. Thin layer chromatography of lichen extracts reveals the presence of two secondary metabolites viz. salazinic acid and usnic acid. U. orientalis extract exhibited promising antidermatophytic activity against all tested pathogens. Amongst all tested pathogens, E. floccosum exhibited most susceptibility towards extract, whereas T. mentagrophytes exhibited the least susceptibility. Topical application of U. orientalis extract might be helpful in the cure of dermal infections.
Subject Areas
antidermatophytic; dermatophytes; DPPH; Lichen
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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