Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biological Activities of the Essential Oil from Erigeron floribundus

Riccardo Petrelli
* ORCID logo ,
Giuseppe Orsomando
,
Leonardo Sorci
,
Filippo Maggi
* ORCID logo ,
Farahnaz Ranjbarian
,
Prosper C. Biapa Nya
,
Dezemona Petrelli
,
Luca A. Vitali
,
Giulio Lupidi
,
Luana Quassinti
,
Massimo Bramucci
,
Anders Hofer
,
Loredana Cappel
ORCID logo
Version 1 : Received: 10 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (12:36:57 CEST)

How to cite: Petrelli, R.; Orsomando, G.; Sorci, L.; Maggi, F.; Ranjbarian, F.; Biapa Nya, P. C.; Petrelli, D.; Vitali, L. A.; Lupidi, G.; Quassinti, L.; Bramucci, M.; Hofer, A.; Cappel, L. Biological Activities of the Essential Oil from Erigeron floribundus. Preprints 2016, 2016080111. https://doi.org/10.20944/preprints201608.0111.v1 Petrelli, R.; Orsomando, G.; Sorci, L.; Maggi, F.; Ranjbarian, F.; Biapa Nya, P. C.; Petrelli, D.; Vitali, L. A.; Lupidi, G.; Quassinti, L.; Bramucci, M.; Hofer, A.; Cappel, L. Biological Activities of the Essential Oil from Erigeron floribundus. Preprints 2016, 2016080111. https://doi.org/10.20944/preprints201608.0111.v1

Abstract

Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in the Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (IZD of 14 mm, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (TEAC= 411.9 μmol TE/g).

Keywords

Erigeron floribundus; essential oil; antimicrobial; NadD; Trypanosoma brucei; cytotoxicity; antioxidant; limonene; caryophyllene oxide

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.